Hydroxysafflor yellow A exerts beneficial effects via restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice.
Exp Physiol. 2019 Dec 05;:
Authors: Luo M, Huang JC, Yang ZQ, Wang YS, Guo B, Yue ZP
NEW FINDINGS: What is the central question of this study? The aim of this study was to evaluate the potential therapeutic role of Ginsenoside Rb1 and HSYA in PCOS. What is the main finding and its importance? The main finding is that HSYA restored the estrous cycles of PCOS mice, reduced follicular cysts in ovaries and rescued the abnormal hormone secretion, while Ginsenoside Rb1 did not ameliorate the main symptoms of PCOS mice. Meanwhile, HSYA alleviated oxidative stress along with the enhancement of antioxidant enzyme activities. These evidences highlight a potential role of HSYA in PCOS therapy.
ABSTRACT: Polycystic ovary syndrome (PCOS) is the most common endocrine disease resulted in woman infertility. Hydroxysafflor yellow A (HSYA) and Ginsenoside Rb1 are shown to have antioxidant properties, but little is known about their impact in PCOS. Here DHEA was used to induce PCOS mouse model which was characterized by irregular estrous cycle, cystic follicles and elevated serum T level. Supplementation of HSYA restored the estrous cycle of PCOS mice and reduced follicular cysts in PCOS mice ovaries along with the decline in serum T level, while Ginsenoside Rb1 did not ameliorate above symptoms of PCOS mice. Meanwhile, after HSYA treatment, elevation of serum E2 , P4 , LH and AMH levels as well as reduction of FSH level exhibited the obvious improvement, but Ginsenoside Rb1 only rescued the levels of FSH and AMH. Further analysis evidenced that HSYA reversed the expression of steroid hormone secretion-related genes Star, Hsd3b1, Cyp11a1 and Cyp19a1. In PCOS mice, HSYA weakened the elevation of ovarian MDA which was regarded as the biomarker for oxidative stress. Moreover, HSYA improved GSH content accompanying with a simultaneous increase in GSH/GSSG ratio and enhanced the activities of antioxidant enzymes SOD, GSH-Px and CAT. Collectively, HSYA exerted beneficial effects on PCOS mice via restoring hormone secretion and alleviating oxidative stress. This article is protected by copyright. All rights reserved.
PMID: 31803965 [PubMed – as supplied by publisher]