https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326049/
https://pubmed.ncbi.nlm.nih.gov/32670195/
www.PCOSTreatmentReport.com
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326049/
https://pubmed.ncbi.nlm.nih.gov/32670195/
https://clinicaltrials.gov/ct2/show/NCT04452968
https://clinicaltrials.gov/ct2/show/NCT04452968?recrs=abdf&type=Intr&cond=Polycystic+Ovary+Syndrome&lupd_s=06%2F17%2F2020&lupd_d=14
Conditions : Polycystic Ovarian Syndrome; Weight Loss; Intermittent Fasting
Interventions : Behavioral: intermittent fasting; Behavioral: Caloric restriction
Sponsors : Karachi Medical and Dental College; Aziz Medical Center
Recruiting
Comparison of Intermittent Fasting and Caloric Deficit for Weight Loss in Women With Polycystic Ovarian Syndrome
NCT04452968
Wed, 01 Jul 2020 12:00:00 EDT
Last Update Posted: 07/01/20 07:49AM
https://academic.oup.com/jcem/article-abstract/doi/10.1210/clinem/dgaa425/5867491?redirectedFrom=fulltext
https://www.ncbi.nlm.nih.gov/pubmed/32621748?dopt=Abstract
Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome.
J Clin Endocrinol Metab. 2020 Jul 04;:
Authors: Shang Y, Zhou H, Hu M, Feng H
Abstract
OBJECTIVE: The effect of diet on insulin resistance (IR) in polycystic ovary syndrome (PCOS) is controversial. Thus, we conducted this systematic review and meta-analysis to evaluate whether diet could reduce IR in women with PCOS while providing optimal and precise nutrition advice for clinical practice.
DESIGN: The search was conducted in eight databases through June 30, 2019. The systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A random-effect model was adopted to calculate the overall effects.
RESULTS: A total of 19 trials (1193 participants) were included. The analysis showed that diet was significantly related to improvements in IR and body composition (e.g., homeostasis model assessment of insulin resistance (HOMA-IR), fasting insulin (FINS), fasting plasma glucose (FPG), body mass index (BMI), weight, and waist circumference (WC)) in PCOS patients. The Dietary Approaches to Stop Hypertension (DASH) diet and calorie-restricted diets might be the optimal choices for reducing IR and improving body composition, respectively, in the PCOS population. Additionally, the effects were associated with the course of treatment. The longer the duration, the greater the improvement was. Compared with metformin, diet was also advantageous for weight loss (including BMI and weight) and had the same effects on insulin regulation.
CONCLUSION: Overall, our findings suggest that diet is an effective, acceptable and safe intervention for relieving IR, and professional dietary advice should be offered to all PCOS patients.
PMID: 32621748 [PubMed – as supplied by publisher]
https://www.sciencedirect.com/science/article/abs/pii/S0378427420303040?via%3Dihub
https://www.ncbi.nlm.nih.gov/pubmed/32629074?dopt=Abstract
High-refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats.
Toxicol Lett. 2020 Jul 03;:
Authors: Niño OMS, da Costa CS, Torres KM, Zanol JF, Freitas-Lima LC, Miranda-Alves L, Graceli JB
Abstract
Obesity is associated with several female reproductive complications, such as polycystic ovary syndrome (PCOS). The exact mechanism of this relationship remains unclear. Few previous studies using diet containing refined carbohydrate (HCD) leading to obesity have been performed and it is unclear if HCD is linked with reproductive dysfunctions. In this investigation, we assessed whether subchronic HCD exposure results in reproductive and other irregularities. Female rats were fed with HCD for 15 days and metabolic outcomes and reproductive tract morphophysiology were assessed. We further assessed reproductive tract inflammation, oxidative stress (OS) and fibrosis. HCD rats displayed metabolic impairments, such as an increase in body weight/adiposity, adipocyte hypertrophic, abnormal lipid profile, glucose tolerance and insulin resistance (IR) and hyperleptinemia. Improper functioning of the HCD reproductive tract was observed. Specifically, irregular estrous cyclicity, high LH levels and abnormal ovarian morphology coupled with reduction in primordial and primary follicle numbers was observed, suggesting ovarian reserve depletion. Improper follicular development and a reduction in antral follicles, corpora lutea and granulosa layer area together with an increase in cystic follicles were apparent. Uterine atrophy and reduction in endometrial gland (GE) number was observed in HCD rats. Reproductive tract inflammation, OS and fibrosis were seen in HCD rats. Further, strong positive correlations were observed between body weight/adiposity and IR with estrous cycle length, cystic follicles, ovarian reserve, GE and other abnormalities. Thus, these data suggest that the subchronic HCD exposure led to PCOS-like features, impaired ovarian reserve, GE number, and other reproductive abnormalities in female rats.
PMID: 32629074 [PubMed – as supplied by publisher]
https://www.frontiersin.org/articles/10.3389/fendo.2020.00284/full
https://www.ncbi.nlm.nih.gov/pubmed/32670195?dopt=Abstract
Dietary flaxseed oil improved PCOS in rats, study finds
Collectively, this study demonstrated that dietary FO ameliorated PCOS through the sex steroid hormones-microbiota-inflammation axis in rats, which may contribute to the understanding of pathogenesis and potentially serve as an inexpensive intervention in the control of PCOS.
Related Articles
Dietary α-Linolenic Acid-Rich Flaxseed Oil Exerts Beneficial Effects on Polycystic Ovary Syndrome Through Sex Steroid Hormones-Microbiota-Inflammation Axis in Rats.
Front Endocrinol (Lausanne). 2020;11:284
Authors: Wang T, Sha L, Li Y, Zhu L, Wang Z, Li K, Lu H, Bao T, Guo L, Zhang X, Wang H
Abstract
Polycystic ovary syndrome (PCOS) represents a common endocrine-metabolic disorder disease with chronic low-grade inflammation and alteration of intestinal flora. Serving as functional food, flaxseed oil (FO), which is rich in plant-derived α-linolenic acid of omega-3 polyunsaturated fatty acids, has been proven to benefit for chronic metabolic diseases. However, the exact role of dietary FO on PCOS remains largely unclear. In the present study, 6-week-old female Sprague-Dawley rats were randomly divided into four groups (eight rats/group), including (a) pair-fed (PF) control (CON) group (PF/CON), (b) FO-fed CON group (FO/CON), (c) PF with letrozole-induced PCOS model (MOD) group (PF/MOD), and (d) FO-fed MOD group (FO/MOD). All rats were fed a standard diet. After 3 weeks of modeling and subsequent 8 weeks of treatment, the rats in diverse groups were euthanized and associated indications were investigated. The results showed that dietary FO ameliorated the disorder of estrous cycle and ovarian morphology. In parallel, dietary FO improved the sex steroid hormone disturbance (luteinizing hormone/follicle-stimulating hormone, estrogen, testosterone, and progesterone), body weights, dyslipidemia, and insulin resistance. Moreover, FO treatment improved plasma and ovary inflammatory interleukin (IL)-1β, IL-6, IL-10, and IL-17A, tumor necrosis factor-α, and monocyte chemoattractant protein-1. Additionally, FO intervention significantly modulated the composition of gut microbiota and vaginal microbiota by increasing the abundances of Allobaculum, Lactobacillus, Butyrivibrio, Desulfovibrio, Bifidobacterium, Faecalibacterium, Parabacteroides as well as decreasing the abundances of Actinobacteria, Bacteroides, Proteobacteria, and Streptococcus, the ratio of Firmicutes/Bacteroidetes. A decrease in plasma lipopolysaccharide level and an increase in short-chain fatty acids, including acetic acid, propionic acid, butyric acid and pentanoic acid, were determined after dietary FO supplementation. Correlation analysis revealed close relationships among sex steroid hormones, inflammation, and gut/vaginal microbiota. Collectively, this study demonstrated that dietary FO ameliorated PCOS through the sex steroid hormones-microbiota-inflammation axis in rats, which may contribute to the understanding of pathogenesis and potentially serve as an inexpensive intervention in the control of PCOS.
PMID: 32670195 [PubMed – in process]
https://www.frontiersin.org/articles/10.3389/fendo.2019.00346/full
https://www.ncbi.nlm.nih.gov/pubmed/31231310?dopt=Abstract
Related Articles
Nutrition and Female Fertility: An Interdependent Correlation.
Front Endocrinol (Lausanne). 2019;10:346
Authors: Silvestris E, Lovero D, Palmirotta R
Abstract
Besides aging, a number of non-modifiable lifestyle-related factors, such as smoking, elevated consumption of caffeine and alcohol, stress, agonist sports, chronic exposure to environmental pollutants, and other nutritional habits exert a negative impact on a women’s fertility. In particular, metabolic disorders including diabetes, obesity, and hyperlipidemia commonly associated to hypercaloric diets are suspected to affect a woman’s fertility either by direct damage to oocyte health and differentiation, or by indirect interference with the pituitary-hypothalamic axis, resulting in dysfunctional oogenesis. Obese women show decreased insulin sensitivity determining persistent hyperinsulinemia, which may be involved in the pathogenesis of Polycystic Ovary Syndrome. Thus, the reduced insulin secretion induced by dietary adjustments is an attractive non-pharmacological treatment to prevent infertility, and a Mediterranean diet aimed at maintaining normal body mass may be effective in the preservation of ovarian health and physiology. Furthermore, in relation to the oxidative stress as a co-factor of defective oocyte maturation, an appropriate intake of proteins, antioxidants and methyl-donor supplements (1-Carbon Cycle) may decrease the bioavailability of toxic oxidants resulting in the protection of oocyte maturation.
PMID: 31231310 [PubMed]